Simvastatin Versus Ezetimibe
نویسندگان
چکیده
منابع مشابه
Ezetimibe/simvastatin 10/20 mg versus simvastatin 40 mg in coronary heart disease patients.
BACKGROUND Reducing low-density lipoprotein cholesterol (LDL-C) is the primary goal of therapy in patients with hypercholesterolemia and coronary heart disease (CHD). METHODS This double blind placebo-controlled study enrolled patients 18 to 75 years of age with primary hypercholesterolemia and established CHD who were taking a stable daily dose of simvastatin 20 mg. Patients were randomized ...
متن کاملEzetimibe + simvastatin versus doubling the dose of simvastatin in high cardiovascular risk diabetics: a multicenter, randomized trial (the LEAD study)
BACKGROUND The primary goal of therapy in patients with hypercholesterolemia and coronary heart disease (CHD) is reducing low-density lipoprotein cholesterol (LDL-C). This was a multicenter, randomized, double-blind, double-dummy study in patients with type 2 diabetes mellitus (T2DM). METHODS Adult patients with T2DM and CHD (N = 93) on a stable dose of simvastatin 20 mg with LDL-C >or= 2.6 m...
متن کاملSimvastatin with or without Ezetimibe in Familial Hypercholesterolemia To the Editor: In the Ezetimibe and Simvastatin in Hypercholesterolemia Enhances Atherosclero-
To the Editor: In the Ezetimibe and Simvastatin in Hypercholesterolemia Enhances Atherosclerosis Regression (ENHANCE) study by Kastelein et al. (April 3 issue),1 the addition of ezetimibe to simvastatin boosted the decrease in levels of low-density lipoprotein (LDL) cholesterol from 39.1% to 55.6%. However, the greater decrease in LDL cholesterol in the combined-therapy group did not affect pro...
متن کاملThe efficacy of statin monotherapy uptitration versus switching to ezetimibe/simvastatin: results of the EASEGO study.
OBJECTIVE To assess the incremental low-density lipoprotein-cholesterol (LDL-C) lowering efficacy of doubling the statin dose or switching to the ezetimibe/simvastatin 10/20 mg combination tablet (EZE/SIMVA) in patients on simvastatin 20 mg or atorvastatin 10 mg not at LDL-C target < 2.5 mmol/L. STUDY DESIGN AND METHODS Patients with documented coronary heart disease (CHD) and/or type 2 diabe...
متن کاملSimvastatin versus ezetimibe: pleiotropic and lipid-lowering effects on endothelial function in humans.
BACKGROUND Statins may exert important pleiotropic effects, ie, improve endothelial function, independently of their impact on LDL cholesterol. In humans, however, pleiotropic effects of statins have never been unequivocally demonstrated because prolonged statin treatment always results in reduced LDL cholesterol levels. We therefore tested the hypothesis that similar reductions in LDL choleste...
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ژورنال
عنوان ژورنال: Circulation
سال: 2005
ISSN: 0009-7322,1524-4539
DOI: 10.1161/01.cir.0000164260.82417.3f